Histidine-rich protein II: a novel approach to malaria drug sensitivity testing.

@article{Noedl2002HistidinerichPI,
  title={Histidine-rich protein II: a novel approach to malaria drug sensitivity testing.},
  author={Harald Noedl and Walther Helmut Wernsdorfer and R. S. Miller and Chansuda Wongsrichanalai},
  journal={Antimicrobial agents and chemotherapy},
  year={2002},
  volume={46 6},
  pages={1658-64}
}
The production of histidine-rich protein II (HRP2), a histidine- and alanine-rich protein produced by Plasmodium falciparum, is closely associated with the development and proliferation of the parasite and therefore is perfectly suited to reflect growth inhibition as a measure of drug susceptibility. It was the aim of the present study to develop a malaria drug sensitivity assay based on the measurement of HRP2 in a simple enzyme-linked immunosorbent assay (ELISA). The new test proved to be as… CONTINUE READING