Histidine-rich glycoprotein promotes bacterial entrapment in clots and decreases mortality in a mouse model of sepsis.

@article{Shannon2010HistidinerichGP,
  title={Histidine-rich glycoprotein promotes bacterial entrapment in clots and decreases mortality in a mouse model of sepsis.},
  author={Oonagh Shannon and Victoria Rydeng{\aa}rd and Artur Schmidtchen and Matthias M{\"o}rgelin and Per Alm and Ole E S\orensen and Lars Bj{\"o}rck},
  journal={Blood},
  year={2010},
  volume={116 13},
  pages={2365-72}
}
Streptococcus pyogenes is a significant bacterial pathogen in humans. In this study, histidine-rich glycoprotein (HRG), an abundant plasma protein, was found to kill S pyogenes. Furthermore, S pyogenes grew more efficiently in HRG-deficient plasma, and clots formed in this plasma were significantly less effective at bacterial entrapment and killing. HRG-deficient mice were strikingly more susceptible to S pyogenes infection. These animals failed to control the infection at the local… CONTINUE READING

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M protein-mediated plasminogen binding is essential for the virulence of an invasive Streptococcus pyogenes isolate.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2008

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