Histidine-rich glycoprotein plus zinc reverses growth inhibition of vascular smooth muscle cells by heparin

@article{Mori2003HistidinerichGP,
  title={Histidine-rich glycoprotein plus zinc reverses growth inhibition of vascular smooth muscle cells by heparin},
  author={Shuji Mori and Ryoko Shinohata and Makoto Renbutsu and Hideo Takahashi and Y I Fang and Kiyonori Yamaoka and Motoi Okamoto and Itaru Yamamoto and Masahiro Nishibori},
  journal={Cell and Tissue Research},
  year={2003},
  volume={312},
  pages={353-359}
}
Vascular smooth muscle cell (SMC) hyperplasia is known to be an important component in the pathogenesis of arteriosclerosis and restenosis. Although heparin has been well recognized as the representative molecule suppressing SMC growth in vitro, attempts to use heparin as a therapeutic anti-restenosis drug have not favorably influenced the angiographic or clinical outcome after angioplasty in some clinical trials. In this study, we have examined the effect of histidine-rich glycoprotein (HRG… CONTINUE READING