Histidine-rich glycoprotein inhibits contact activation of blood coagulation.

  title={Histidine-rich glycoprotein inhibits contact activation of blood coagulation.},
  author={A B Vestergaard and Henning Friis Andersen and Sigurdur M. Magnusson and Torben Halkier},
  journal={Thrombosis research},
  volume={60 5},
Histidine-rich glycoprotein has been purified from bovine plasma employing two different purification procedures. The first procedure was one-step ion-exchange chromatography using phosphocellulose, while the second procedure involved fractionation using polyethyleneglycol 6000 followed by column chromatography employing CM-Sepharose and heparin-Sepharose. The effect of purified bovine histidine-rich glycoprotein on the contact activation of blood coagulation was studied in human plasma by… CONTINUE READING