Histidine-rich glycoprotein binds factor XIIa with high affinity and inhibits contact-initiated coagulation.

@article{MacQuarrie2011HistidinerichGB,
  title={Histidine-rich glycoprotein binds factor XIIa with high affinity and inhibits contact-initiated coagulation.},
  author={Jessica L MacQuarrie and Alan Ray Stafford and Jonathan W. Yau and Beverly A. Leslie and Trang T. Vu and James C Fredenburgh and Jeffrey I Weitz},
  journal={Blood},
  year={2011},
  volume={117 15},
  pages={
          4134-41
        }
}
Histidine-rich glycoprotein (HRG) circulates in plasma at a concentration of 2μM and binds plasminogen, fibrinogen, and thrombospondin. Despite these interactions, the physiologic role of HRG is unknown. Previous studies have shown that mice and humans deficient in HRG have shortened plasma clotting times. To better understand this phenomenon, we examined the effect of HRG on clotting tests. HRG prolongs the activated partial thromboplastin time in a concentration-dependent fashion but has no… CONTINUE READING

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