Histidine provides long-term neuroprotection after cerebral ischemia through promoting astrocyte migration

@inproceedings{Liao2015HistidinePL,
  title={Histidine provides long-term neuroprotection after cerebral ischemia through promoting astrocyte migration},
  author={Ru-jia Liao and Lei Jiang and Rong-rong Wang and Hua-wei Zhao and Yin Chen and Ya Li and L. J. Wang and Li-Yong Jie and Yu-Dong Zhou and Xiang-nan Zhang and Zhong Chen and Weiwei Hu},
  booktitle={Scientific reports},
  year={2015}
}
The formation of glial scar impedes the neurogenesis and neural functional recovery following cerebral ischemia. Histamine showed neuroprotection at early stage after cerebral ischemia, however, its long-term effect, especially on glial scar formation, hasn't been characterized. With various administration regimens constructed for histidine, a precursor of histamine, we found that histidine treatment at a high dose at early stage and a low dose at late stage demonstrated the most remarkable… CONTINUE READING