Histidine phosphorylation of the potassium channel KCa3.1 by nucleoside diphosphate kinase B is required for activation of KCa3.1 and CD4 T cells.

@article{Srivastava2006HistidinePO,
  title={Histidine phosphorylation of the potassium channel KCa3.1 by nucleoside diphosphate kinase B is required for activation of KCa3.1 and CD4 T cells.},
  author={Shekhar Srivastava and Zhai Li and Kyung Haeng Ko and Papiya Choudhury and Mamdouh Nasser Albaqumi and Amanda K. Johnson and Ying Jun Yan and Jonathan M. Backer and Derya Unutmaz and William A Coetzee and Edward Y Skolnik},
  journal={Molecular cell},
  year={2006},
  volume={24 5},
  pages={665-675}
}
The Ca2+ -activated K+ channel KCa3.1 is required for Ca2+ influx and the subsequent activation of B and T cells. Inhibitors of KCa3.1 are in development to treat autoimmune diseases and transplant rejection, underscoring the importance in understanding how these channels are regulated. We show that nucleoside diphosphate kinase B (NDPK-B), a mammalian histidine kinase, functions downstream of PI(3)P to activate KCa3.1. NDPK-B directly binds and activates KCa3.1 by phosphorylating histidine 358… CONTINUE READING

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