Histidine decarboxylase in rat stomach ECL cells: relationship between enzyme activity and different molecular forms.

@article{Dartsch1999HistidineDI,
  title={Histidine decarboxylase in rat stomach ECL cells: relationship between enzyme activity and different molecular forms.},
  author={Christine Dartsch and Duan Chen and Rolf H{\aa}kanson and Lo Persson},
  journal={Regulatory peptides},
  year={1999},
  volume={81 1-3},
  pages={41-8}
}
Mammalian HDC mRNA encodes a protein with a molecular mass of 74 kDa. The reported molecular mass for the purified HDC subunit is 53-55 kDa. Western blot analysis of extracts of rat gastric mucosa and fetal rat liver has revealed the presence of at least three different forms of HDC immunoreactivity, having molecular masses of about 74, 63 and 53 kDa. There is evidence from previous studies that full length rat HDC is enzymatically inactive and that activation requires C-terminal truncation. In… CONTINUE READING

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Mammalian histidine decarboxylase: from structure to function.

BioEssays : news and reviews in molecular, cellular and developmental biology • 2005
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