Histidine biosynthesis in plants

@article{Stepansky2005HistidineBI,
  title={Histidine biosynthesis in plants},
  author={Asya Stepansky and Thomas Leustek},
  journal={Amino Acids},
  year={2005},
  volume={30},
  pages={127-142}
}
Summary.The study of histidine metabolism has never been at the forefront of interest in plant systems despite the significant role that the analysis of this pathway has played in development of the field of molecular genetics in microbes. With the advent of methods to analyze plant gene function by complementation of microbial auxotrophic mutants and the complete analysis of plant genome sequences, strides have been made in deciphering the histidine pathway in plants. The studies point to a… 

Histidine Biosynthesis

  • R. Ingle
  • Biology, Chemistry
    The arabidopsis book
  • 2011
TLDR
All the enzymes of His biosynthesis have now been identified in Arabidopsis, and several lines of evidence have implicated ATP-phosphoribosyl transferase as playing an important role in the regulation of this pathway.

Biosynthesis of Histidine.

TLDR
This article reviews the structure and regulation of the histidine (his) biosynthetic operon, including transcript processing, Rho-factor-dependent "classical" polarity, and the current model of his operon attenuation control, and focuses on areas of recent progress.

Relative contributions of nine genes in the pathway of histidine biosynthesis to the control of free histidine concentrations in Arabidopsis thaliana.

TLDR
A strong positive correlation was observed between free His content and biomass production, indicating that the metabolic cost of His overproduction was outweighed by the benefit of increased tolerance to Ni, and chemical selectivity in intracellular metal binding by His.

Genetic Dissection of Histidine Biosynthesis in Arabidopsis1[W][OA]

TLDR
These knockout mutants document the importance of His biosynthesis for plant growth and development, provide valuable insights into amino acid transport and source-sink relationships during seed development, and represent a significant addition to the limited collection of well-characterized auxotrophs in flowering plants.

Histidine biosynthesis, its regulation and biotechnological application in Corynebacterium glutamicum

TLDR
This review summarizes the current knowledge of l‐histidine biosynthesis in Corynebacterium glutamicum and discusses the potential of using this knowledge to create or improve C. glutamicum strains for the industrial l‐ histidine production.

3. Histidine biosynthesis pathway: A test case for engineering plant metabolism and growth

TLDR
This chapter uses the histidine biosynthesis pathway to examine a particular step-wise approach for identifying the nodes in a metabolic pathway that are most amenable to pathway engineering.

Functional Analysis of a Histidine Auxotrophic Mutation in Gibberella zeae

TLDR
It is demonstrated that correct histidine biosynthesis is essential for virulence, as well as sexual development, in G. zeae, and this is the first report of the molecular characterization of histidine auxotrophy in the fungus.

PA0335, a Gene Encoding Histidinol Phosphate Phosphatase, Mediates Histidine Auxotrophy in Pseudomonas aeruginosa

TLDR
It is found that the growth defect was due to incomplete histidine auxotrophy caused by PA0335 inactivation, and the histidine synthesis pathway of P. aeruginosa might be used as elements of histidine synthetic biology in other industrial microorganisms.

Guarding the gateway to histidine biosynthesis in plants: Medicago truncatula ATP-phosphoribosyltransferase in relaxed and tense states.

TLDR
Two crystal structures, presenting homohexameric MedtrATP-PRT1 in its relaxed and histidine-bound, tense states allowed to observe key features of the enzyme and provided the first structural insights into an ATP-PRTs from a eukaryotic organism.

Regulation of amino acid metabolic enzymes and transporters in plants.

TLDR
This review focuses mainly on the current state of the understanding of the regulation of the enzymes and transporters at the transcript level and hints at multiple, complex levels of regulation that control and coordinate transport and enzyme activities.
...

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TLDR
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