Histidine biosynthesis in plants

  title={Histidine biosynthesis in plants},
  author={Asya Stepansky and Thomas Leustek},
  journal={Amino Acids},
Summary.The study of histidine metabolism has never been at the forefront of interest in plant systems despite the significant role that the analysis of this pathway has played in development of the field of molecular genetics in microbes. With the advent of methods to analyze plant gene function by complementation of microbial auxotrophic mutants and the complete analysis of plant genome sequences, strides have been made in deciphering the histidine pathway in plants. The studies point to a… 

Histidine Biosynthesis

  • R. Ingle
  • Biology, Chemistry
    The arabidopsis book
  • 2011
All the enzymes of His biosynthesis have now been identified in Arabidopsis, and several lines of evidence have implicated ATP-phosphoribosyl transferase as playing an important role in the regulation of this pathway.

Biosynthesis of Histidine.

This article reviews the structure and regulation of the histidine (his) biosynthetic operon, including transcript processing, Rho-factor-dependent "classical" polarity, and the current model of his operon attenuation control, and focuses on areas of recent progress.

Relative contributions of nine genes in the pathway of histidine biosynthesis to the control of free histidine concentrations in Arabidopsis thaliana.

A strong positive correlation was observed between free His content and biomass production, indicating that the metabolic cost of His overproduction was outweighed by the benefit of increased tolerance to Ni, and chemical selectivity in intracellular metal binding by His.

Genetic Dissection of Histidine Biosynthesis in Arabidopsis1[W][OA]

These knockout mutants document the importance of His biosynthesis for plant growth and development, provide valuable insights into amino acid transport and source-sink relationships during seed development, and represent a significant addition to the limited collection of well-characterized auxotrophs in flowering plants.

Histidine biosynthesis, its regulation and biotechnological application in Corynebacterium glutamicum

This review summarizes the current knowledge of l‐histidine biosynthesis in Corynebacterium glutamicum and discusses the potential of using this knowledge to create or improve C. glutamicum strains for the industrial l‐ histidine production.

3. Histidine biosynthesis pathway: A test case for engineering plant metabolism and growth

This chapter uses the histidine biosynthesis pathway to examine a particular step-wise approach for identifying the nodes in a metabolic pathway that are most amenable to pathway engineering.

Functional Analysis of a Histidine Auxotrophic Mutation in Gibberella zeae

It is demonstrated that correct histidine biosynthesis is essential for virulence, as well as sexual development, in G. zeae, and this is the first report of the molecular characterization of histidine auxotrophy in the fungus.

PA0335, a Gene Encoding Histidinol Phosphate Phosphatase, Mediates Histidine Auxotrophy in Pseudomonas aeruginosa

It is found that the growth defect was due to incomplete histidine auxotrophy caused by PA0335 inactivation, and the histidine synthesis pathway of P. aeruginosa might be used as elements of histidine synthetic biology in other industrial microorganisms.

Guarding the gateway to histidine biosynthesis in plants: Medicago truncatula ATP-phosphoribosyltransferase in relaxed and tense states.

Two crystal structures, presenting homohexameric MedtrATP-PRT1 in its relaxed and histidine-bound, tense states allowed to observe key features of the enzyme and provided the first structural insights into an ATP-PRTs from a eukaryotic organism.

Regulation of amino acid metabolic enzymes and transporters in plants.

This review focuses mainly on the current state of the understanding of the regulation of the enzymes and transporters at the transcript level and hints at multiple, complex levels of regulation that control and coordinate transport and enzyme activities.



Functional genomics study in Arabidopsis thaliana of histidine biosynthesis

  • Biology
The fact that the homozygous mutant seeds fail to grow while the maternal plant thrives suggests that histidine, unlike other amino acids, cannot be transported from the maternal Plant to developing embryos.

Evidence for cross-pathway regulation of metabolic gene expression in plants.

  • D. GuyerD. PattonE. Ward
  • Biology, Environmental Science
    Proceedings of the National Academy of Sciences of the United States of America
  • 1995
In Arabidopsis thaliana, blocking histidine biosynthesis with a specific inhibitor of imidazoleglycerol-phosphate dehydratase caused increased expression of eight genes involved in the biosynthesis of aromatic amino acids, histidine, lysine, and purines, demonstrating that plants are capable of cross-pathway metabolic regulation.

The genetic control of the enzymes of histidine biosynthesis in Salmonella typhimurium.

It has been found that the level of activity of the series of enzymes of Histidine biosynthesis can be raised about 15-fold over the wild-type level by growing a histidine-requiring mutant on formylhistidine as a source of histidine.

Chromosomal alterations affecting the regulation of histidine biosynthetic enzymes in Salmonella.

Role of the Myb‐like protein Bas1p in Saccharomyces cerevisiae: a proteome analysis

The expression of two pyrimidine biosynthesis genes URA1 and URA3 was found to be severely affected by bas1 and bas2 mutations in the absence of adenine, establishing a regulatory link between the two nucleotide biosynthesis pathways.

Tryptophan biosynthesis and metabolism: biochemical and molecular genetics.

ALBINO AND PALE GREEN 10 encodes BBMII isomerase involved in histidine biosynthesis in Arabidopsis thaliana.

The histidine limitation induced by apg10 mutation causes dynamic changes of the free amino acid profile, suggesting the existence of a cross-pathway regulatory mechanism of amino acid biosynthesis in plants.

Constitutively High Expression of the Histidine Biosynthetic Pathway Contributes to Nickel Tolerance in Hyperaccumulator Plantsw⃞

Results suggest that ATP-PRT expression plays a major role in regulating the pool of free His and contributes to the exceptional Ni tolerance of hyperaccumulator Alyssum species.

Molecular dissection of the role of histidine in nickel hyperaccumulation in Thlaspi goesingense (Hálácsy).

The Ni hyperaccumulation phenotype in T. goesingense is not determined by the overproduction of His in response to Ni, and the regulation of His biosynthesis at both the molecular and biochemical levels is investigated.