Histidine 140 plays a key role in the inhibitory modulation of the P2X4 nucleotide receptor by copper but not zinc.

@article{Coddou2003Histidine1P,
  title={Histidine 140 plays a key role in the inhibitory modulation of the P2X4 nucleotide receptor by copper but not zinc.},
  author={Claudio Coddou and Bernardo Morales and Jorge Luis G{\'o}mez Gonz{\'a}lez and Marta Grauso and Felipe Gordillo and Paulina Bull and François A. Rassendren and Juan Pablo Huidobro-Toro},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 38},
  pages={36777-85}
}
To elucidate the role of extracellular histidines in the modulation of the rat P2X4 receptor by trace metals, we generated single, double, and triple histidine mutants for residues 140, 241, and 286, replacing them with alanines. cDNAs for the wild-type and receptor mutants were expressed in Xenopus laevis oocytes and in human embryonic kidney 293 cells and… CONTINUE READING