Histidinaemia: a child and his family.


Histidinaemia, an inherited disorder of histidine metabolism, was first described by Ghadimi, Partington, and Hunter in 1961. The principal metabolic pathway for histidine is through urocanic acid and formiminoglutamic acid (FIGLU) to glutamic acid (Fig. 1). Zannoni and La Du (1963) demonstrated that histidase, the enzyme necessary for the conversion of… (More)


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