Histaminintoleranz - aktueller Stand der Technik von Diagnose und Therapie

  title={Histaminintoleranz - aktueller Stand der Technik von Diagnose und Therapie},
  author={M. Pfisterer and I. Mayer},
In der klinischen Praxis steht der Arzt oft Patienten gegenuber, die uber monate- oder jahrelang andauernde chronische Be- schwerden wie Kopfschmerzen, Magen- Darm-Probleme, hohen oder niedrigen Blutdruck, Hautausschlage usw. klagen. Die Symptome a einer Allergie, Aller- gietests sind jedoch negativ. Diese Patien- ten haben oft jahrelange Odysseen durch Arztpraxen und Spezialkliniken hinter sich. Therapieansatze werden mangels Er- folg oft abgebrochen. Da die Ursache der Symptome unerkannt… 


Food-induced histaminosis as an epidemiological problem: Plasma histamine elevation and haemodynamic alterations after oral histamine administration and blockade of diamine oxidase (DAO)
The results contradict the current opinion that oral histamine intake in food is not clinically relevant, especially since many commonly used drugs are DAO-inhibitors and approximately 20% of the authors' population take these drugs.
Histamine‐free diet: treatment of choice for histamine‐induced food intolerance and supporting treatment for chronical headaches
  • F. Wantke, M. Götz, R. Jarisch
  • Medicine
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 1993
The role of histamine in food and wine intolerance is indicated and that histamine‐rich food causes a worsening of symptoms in patients suffering from chronic headaches and the hypothesis of a deficiency of diamine oxidase in patients with intolerance to food or wine is supported.
The treatment of food-induced urticaria consists of elimination the offending food or substance from the diet, use of antihistamines and immunotherapy, and the gold standard in diagnosis is double blind placebo-controlled food test.
Histamine inactivation in the colon of pigs in relationship to abundance of catabolic enzymes
Permeation, but not the relative efficiency of catabolism, of histamine depends on epithelial/paracellular tightness, while DAO activity seems to be more variable and limiting for the overall efficiency of the catabolic process.
Inhibition of in vivo histamine metabolism in rats by foodborne and pharmacologic inhibitors of diamine oxidase, histamine N-methyltransferase, and monoamine oxidase.
The inhibitors could potentiate food poisoning caused by histamine by inhibiting its metabolism and were found to be more potent and have a longer duration of action than foodborne ones.
Inhibition of diamine oxidase promotes uptake of putrescine from rat small intestine
The results suggest that intestinal diamine oxidase clears the blood from diamines and prevents luminal uptake of putrescine in anaesthetized rats.
Determination of diamine oxidase activity in normal human blood serum.
The method with 14C-putrescine as the substrate for routine measurement of serum (plasma) diamine oxidase (histaminase) during pregnancy, and mola hydatidosa (chorionepitelioma) has been modified.
Purification and characterization of diamine oxidase from porcine kidney and intestine.
The diamine oxidase proteins from porcine kidney and intestine are very likely identical and constitute the only diamine oxidation activity present in these tissues, implying identical functions of the proteins in these organs, namely the protection of the organism against high concentrations of diamines.
Histamine and ascorbic acid in human blood.
  • C. Clemetson
  • Chemistry, Medicine
    The Journal of nutrition
  • 1980
Analysis of 437 human blood samples has shown that when the plasma-reduced ascorbic acid level falls below 1 mg/100 ml, the whole blood histamine level increases exponentially as the ascorbic acid
Die verschiedenen Gesichter der Histamin-Intoleranz
  • Deutsches Ärzteblatt
  • 2006