Histaminergic regulation of NK cells. Role of monocyte-derived reactive oxygen metabolites.

@article{Hellstrand1994HistaminergicRO,
  title={Histaminergic regulation of NK cells. Role of monocyte-derived reactive oxygen metabolites.},
  author={Kristoffer Hellstrand and Alexzander Asea and Claes Dahlgren and Svante H. Hermodsson},
  journal={Journal of immunology},
  year={1994},
  volume={153 11},
  pages={
          4940-7
        }
}
Monocytes, recovered by centrifugal elutriation, effectively inhibit functions of human NK cells in vitro. Histamine, acting via monocyte H2-type histamine receptors, abrogates the inhibitory signal. The aim of this study was to define the histamine-reversible mechanism by which monocytes inhibit NK cells with special reference to the respiratory burst activity of monocytes. Monocytes recovered from patients with chronic granulomatous disease did not suppress NK cell function, indicating the… CONTINUE READING

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