Corpus ID: 22044355

Histaminergic mechanisms in experimental convulsions.

  title={Histaminergic mechanisms in experimental convulsions.},
  author={P Sen and N Khanna and Arunabha Ray},
  journal={Indian journal of experimental biology},
  volume={29 4},
  • P Sen, N Khanna, Arunabha Ray
  • Published 1991
  • Biology, Medicine
  • Indian journal of experimental biology
  • Effect of some histamine (HA) agonists and antagonists were assessed on electroshock (MES) convulsions in mice and rats. In mice, pretreatment with the HA precursor, l-histidine (100, 500 and 1000 mg/kg) precipitated seizures after a subthreshold (30 mA) stimulus. Both incidence (%) and tonic hind limb extensor phase (THE) were more than that in vehicle treated controls. The H1 blockers, pheniramine (25 mg/kg) and promethazine (25 mg/kg) both protected against (60 mA) MES and both incidence of… CONTINUE READING