Histaminergic mechanism of motion sickness. Neurochemical and neuropharmacological studies in rats.

@article{Takeda1986HistaminergicMO,
  title={Histaminergic mechanism of motion sickness. Neurochemical and neuropharmacological studies in rats.},
  author={Noriaki Takeda and Masahiro Morita and Takeshi Kubo and Atsushi Yamatodani and Takashi Watanabe and Hiroshi Wada and Takashi Matsunaga},
  journal={Acta oto-laryngologica},
  year={1986},
  volume={101 5-6},
  pages={416-21}
}
Rats were rotated about two parallel axes to produce motion sickness, and the histamine levels in their hypothalamus and pons-medulla oblongata were measured. Rotation for 60 min induced kaolin intake, which is a behavioral index of motion sickness in rats, and increased the histamine levels in the hypothalamus and pons-medulla oblongata, the highest levels occurring after 15 min of rotation. In bilaterally labyrinthectomized rats, no rise in histamine level was observed. alpha… CONTINUE READING

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