Histamine.

Abstract

Histamine is a potent mediator of immediate hypersensitivity reactions, and is stored primarily in mast cells and basophils. It exerts its pharmacologic effects through interactions with H1 and H2 cell surface receptors, which promote changes in vascular permeability, levels of cyclic nucleotides, neutrophil and eosinophil chemokinesis and chemotaxis… (More)

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