Histamine synthesis by non-mast cells through mitogen-dependent induction of histidine decarboxylase.

@article{Oh1988HistamineSB,
  title={Histamine synthesis by non-mast cells through mitogen-dependent induction of histidine decarboxylase.},
  author={Chulhong Oh and Seiji Suzuki and Izumi Nakashima and Kazuo Yamashita and Kouichi Nakano},
  journal={Immunology},
  year={1988},
  volume={65 1},
  pages={143-8}
}
Culture of spleen cells of C57BL/6 mice led to a spontaneous increase in activity of histidine decarboxylase (HDC) in the cell and the medium. Concomitantly histamine increased in the cells and, especially, in the medium. Addition of concanavalin A (Con A) or lipopolysaccharide (LPS) to the culture enhanced these processes. There was also a significant Con… CONTINUE READING