Histamine synthesis by cells of the macrophage lineage in bone marrow of mice.

@article{Takamatsu1995HistamineSB,
  title={Histamine synthesis by cells of the macrophage lineage in bone marrow of mice.},
  author={Seigoh Takamatsu and Kouichi Nakano},
  journal={Bioscience, biotechnology, and biochemistry},
  year={1995},
  volume={59 8},
  pages={1493-7}
}
An injection of Escherichia coli lipopolysaccharide (LPS) increased the activity of histidine decarboxylase (HDC) in bone marrow (BM) cells of C3H/HeN mice much more than in C3H/HeJ mice, which are resistant to various effects of LPS. In WBB6/F1 (W/Wv) mice, which are genetically deficient in mast cells, HDC activity increased more than in C3H/HeN mice. Cultured BM cells of W/Wv mice spontaneously synthesized histamine in a HDC-dependent way. LPS caused a slight increase in HDC-associated… CONTINUE READING