Histamine secretion induced byN-acetyl cysteine

@article{Barrett1985HistamineSI,
  title={Histamine secretion induced byN-acetyl cysteine},
  author={Kim E Barrett and Joshua Minor and Dean D Metcalfe},
  journal={Agents and Actions},
  year={1985},
  volume={16},
  pages={144-146}
}
The mucolytic drugN-acetyl cysteine has been shown to release histamine from cultured mouse mast cells and from human basophils. At neutral pH the release was moderate and non-cytotoxic. If the acidity of the drug was not neutralized, this histamine release was markedly potentiated, but was then associated with a reduction in the viability of the cells. However, the high level of release could not be reproduced by simply exposing the cells to an acidic medium. The results are discussed in terms… CONTINUE READING
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