Corpus ID: 39904442

Histamine release inhibition in anti-inflammatory mechanism.

@article{Yamasaki1970HistamineRI,
  title={Histamine release inhibition in anti-inflammatory mechanism.},
  author={Hidemasa Yamasaki and Kenji Tasaka and Kiyomi Saeki and Sh{\^o}zo Irino},
  journal={Acta medicinae Okayama},
  year={1970},
  volume={24 2},
  pages={
          113-29
        }
}
Rats were depleted of skin histamine by more than 80 % by intraperitoneal injections of sinomenine with daily increasing doses for 6 days. In these rats, egg-white edema induced in the hind paws was inhibited by 68 % of control. The weight of the wall of granuloma pouch made by croton oil was also evidently smaller in the rat treated similarly with sinomenine than that of control. This suggests an important role of histamine participating in the inflammation. It has been observed that a variety… Expand
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References

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1. A method was described for a fairly accurate judgement of the effect of drugs inhibiting the edema in hind paws of a rat caused by local injection of egg white. 2. The degree of inhibition ofExpand
Granuloma pouch and skin histamine of the rat
Using the granuloma pouch technique of SELYE, effect of modification in local histamine on the inflammatory tissue reactions was examined in rats. The increase in the weight of pouch wall andExpand
The analgesic effect induced by repeated administration of histamine and histamine liberators.
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TLDR
The present writer has confirmed the occurrence of analgesia as a result of daily subcutaneous injection of Histamine in mice and found similar analgesia to develop by daily injection of histamine liberators, in spite of the fact that the animals in this case became more susceptible to histamine contrary to the case of histamines desensitization. Expand
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TLDR
There is a marked difference in the response to intradermal histamine and plasma kinins, and 5-Hydroxytryptamine is another naturally occurring substance which possesses some of the actions which characterize inflammation. Expand
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TLDR
Tissue proteolysis induced by the agents investigated in this work results from the action of a protease present in normal tissues as an inactive precursor, which seems to be different from the serum kinase which has been shown to be related to complement. Expand
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TLDR
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A comparison of the slopes of the concentration–response curves for sodium salicylate and acetyl-salicylic acid shows similarities, and it is shown that both compounds inhibit the growth of wheat coleoptiles. Expand
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The mechanism, whereby histamine and serotonin increase the permeability of blood vessels, was studied in the rat by means of the electron microscope, and electron microscopic findings suggested that the endothelial cells become partially disconnected along the intercellular junctions. Expand
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TLDR
After injury changes in concentration of histamine in unaffected parts of the skin in the albino rat are examined to provide a partial answer to the problem of how normal tissue histamine behaves during the period when injury or allergy are liberating histamines in some part of the body. Expand
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TLDR
A tenous chain of connectlion between drugs that exert effects that are anti-inflammatory, anti-“cell necrosis,” and anti-ion transport is found; and it is not surprising that ouabain has no effect on the inflammatory response, but is a protective agent and an effective inhibitor of active transport in liver. Expand
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