Histamine release in the basal forebrain mediates cortical activation through cholinergic neurons.

@article{Zant2012HistamineRI,
  title={Histamine release in the basal forebrain mediates cortical activation through cholinergic neurons.},
  author={Janneke C. Zant and Stanislav V. Rozov and Henna-Kaisa M. Wigren and Pertti Panula and Tarja Porkka-Heiskanen},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2012},
  volume={32 38},
  pages={13244-54}
}
The basal forebrain (BF) is a key structure in regulating both cortical activity and sleep homeostasis. It receives input from all ascending arousal systems and is particularly highly innervated by histaminergic neurons. Previous studies clearly point to a role for histamine as a wake-promoting substance in the BF. We used in vivo microdialysis and pharmacological treatments in rats to study which electroencephalogram (EEG) spectral properties are associated with histamine-induced wakefulness… CONTINUE READING

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