Histamine release in human subjects by modified gelatin (Haemaccel) and dextran: an explanation for anaphylactoid reactions observed under clinical conditions?

@article{Lorenz1976HistamineRI,
  title={Histamine release in human subjects by modified gelatin (Haemaccel) and dextran: an explanation for anaphylactoid reactions observed under clinical conditions?},
  author={Wilfried Lorenz and Alfred W Doenicke and K. Messmer and HA. Reimann and Margot Thermann and W. Lahn and J Berr and Anton Schmal and Petra Dormann and P Regenfuss and Horst Hamelmann},
  journal={British journal of anaesthesia},
  year={1976},
  volume={48 2},
  pages={151-65}
}
Histamine release by modified gelatin (Haemaccel) and dextran (Macrodex) has been demonstrated in volunteers by direct and indirect methods. In a pilot study of Haemaccel, histamine release was observed in six of seven volunteers. The highest plasma histamine concentration was 4.8 ng/ml, the lowest 1.7 ng/ml: two of the subjects showed slight allergic reactions. Using Haemaccel batch 2551, 10 out of 12 subjects reacted to the rapid infusion of Haemaccel with increased plasma histamine… CONTINUE READING