Histamine release by platelet aggregation

Coincubation of rat serosal mast cells with human platelets leads to a significant release of histamine, which dose-dependently increases when platelet aggregation is induced by various concentrations of arachidonic acid. In turn, histamine enhances platelet aggregation induced by different agonists, this effect being mimicked by pyridyl-ethyl-amine (PEA… CONTINUE READING