Histamine release and therapy of severe dermatographism.

  title={Histamine release and therapy of severe dermatographism.},
  author={J Garafalo and Allen P. Kaplan},
  journal={The Journal of allergy and clinical immunology},
  volume={68 2},
A case of unusually severe dermatographism is reported in which baseline plasma histamine levels were repeatedly elevated and histamine release into the circulation was demonstrable upon challenge by scratching the skin. Passive transfer was positive when the patient was challenged after a 48-hr interval, and the responsible factor was heat labile… CONTINUE READING