Histamine regulation of microglia: Gene-environment interaction in the regulation of central nervous system inflammation

@article{Frick2016HistamineRO,
  title={Histamine regulation of microglia: Gene-environment interaction in the regulation of central nervous system inflammation},
  author={Luciana R Frick and Maximiliano Rapanelli and Eeman Abbasi and Hiroshi Ohtsu and Christopher Pittenger},
  journal={Brain, Behavior, and Immunity},
  year={2016},
  volume={57},
  pages={326-337}
}
Microglia mediate neuroinflammation and regulate brain development and homeostasis. Microglial abnormalities are implicated in a range of neuropsychiatric pathology, including Tourette syndrome (TS) and autism. Histamine (HA) is both a neurotransmitter and an immune modulator. HA deficiency has been implicated as a rare cause of TS and may contribute to other neuropsychiatric conditions. In vitro studies suggest that HA can regulate microglia, but this has never been explored in vivo. We used… CONTINUE READING
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