Histamine regulates growth of malignant melanoma implants via H2 receptors in mice

Abstract

The present study examined the effect of histamine H2-receptor antagonists and exogenous histamine on growth of malignant melanoma implant in mice. Drugs were administered to B16BL6 malignant-melanoma-implanted syngeneic mice, and the tumor volume was measured throughout the experiments. Cell proliferation was assessed by MTT assay and mRNA expression was… (More)
DOI: 10.1163/156856005774423917

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