Histamine regulates cytokine production in maturing dendritic cells, resulting in altered T cell polarization.

Abstract

Atopic diseases such as allergy and asthma are characterized by increases in Th2 cells and serum IgE antibodies. The binding of allergens to IgE on mast cells triggers the release of several mediators, of which histamine is the most prevalent. Here we show that histamine, together with a maturation signal, acts directly upon immature dendritic cells (iDCs… (More)
DOI: 10.1172/JCI13930

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Cite this paper

@article{Mazzoni2001HistamineRC, title={Histamine regulates cytokine production in maturing dendritic cells, resulting in altered T cell polarization.}, author={Alessandra Mazzoni and Howard A Young and Jessica H. Spitzer and Alessia Visintin and David M. Segal}, journal={The Journal of clinical investigation}, year={2001}, volume={108 12}, pages={1865-73} }