Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors

@article{Jutel2001HistamineRT,
  title={Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors},
  author={Marek Jutel and Takeshi Watanabe and Sven Klunker and M{\"u}beccel Akdis and Olivier A. R. Thomet and J{\'o}zef Malolepszy and Teresa Żak-Nejmark and Ritsuko Koga and Takashi Kobayashi and Kurt Blaser and Cezmi A. Akdis},
  journal={Nature},
  year={2001},
  volume={413},
  pages={420-425}
}
Many pathological processes, including those causing allergies and autoimmune diseases, are associated with the presence of specialized subsets of T helper cells (TH1 and TH2) at the site of inflammation. The diversity of TH1 and TH2 function is not predetermined but depends on signals that drive the cells towards either subset. Histamine, released from effector cells (mast cells and basophils) during inflammatory reactions can influence immune response. Here we report that histamine enhances… CONTINUE READING
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