Histamine reduces ZO-1 tight-junction protein expression in cultured retinal microvascular endothelial cells.

@article{Gardner1996HistamineRZ,
  title={Histamine reduces ZO-1 tight-junction protein expression in cultured retinal microvascular endothelial cells.},
  author={Thomas W. Gardner and Treena Lesher and Sonny A. Khin and Colynda Vu and Alistair J. Barber and William A Brennan},
  journal={The Biochemical journal},
  year={1996},
  volume={320 ( Pt 3)},
  pages={717-21}
}
We examined ZO-1 protein content in cultured retinal vascular endothelial cells to test the hypothesis that histamine alters tight-junction-protein expression. Histamine (10(-9) -10(-4) M) causes a reversible concentration-dependent reduction of ZO-1 protein content, mediated by both H1 and H2 receptors. Histamine reduces ZO-1 expression within the time associated with increased paracellular permeability. Tight-junction-protein alterations may be a novel explanation for the mechanism by which… CONTINUE READING

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