Histamine receptors in neoplastic transformation: Studies in human cell lines


We have previously reported that N-nitroso-N-methylurea (NMU)-induced experimental carcinomas express H] and H2 histamine receptors with an atypicallinkage to signal transducers [1, 2]. Similarly, carcinomas and benign lesions of the human mammary gland express functional histamine receptors. Furthermore, changes in the normal association ofH2 receptors with transductional pathways are observed as a consequence of the neoplastic transformation [3, 4]. In the present work we investigated the expression of histamine H 1 and H2 receptors in different cell lines, in order to elucidate a possible role for histamine in neoplastic transformation of the mammary gland.

DOI: 10.1007/BF03354090

2 Figures and Tables

Cite this paper

@article{Davio1996HistamineRI, title={Histamine receptors in neoplastic transformation: Studies in human cell lines}, author={Carlos A. Davio and Alejandro Gustavo Mladovan and Conrad Shayo and Bibiana Lemos and Alberto Baldi and E. S. Rivera}, journal={Inflammation Research}, year={1996}, volume={45}, pages={S62-S63} }