Histamine receptor subtypes mediating hyperpolarization in the isolated, perfused rat mesenteric pre-arteriolar bed.

@article{Adeagbo1998HistamineRS,
  title={Histamine receptor subtypes mediating hyperpolarization in the isolated, perfused rat mesenteric pre-arteriolar bed.},
  author={Ayotunde S. O. Adeagbo and M Oriowo},
  journal={European journal of pharmacology},
  year={1998},
  volume={347 2-3},
  pages={237-44}
}
Histamine is a general dilator of rat blood vessels. We investigated the relative contribution of receptor subtypes to the rat mesenteric dilator responses initiated by histamine and related agonists. Histamine initiated dose, and endothelium-dependent, dilation of constricted mesenteric beds with an ED50 of 0.4 +/- 0.1 nmol. The ED50 was increased 10-fold… CONTINUE READING