Histamine receptor 2 modifies dendritic cell responses to microbial ligands.

  title={Histamine receptor 2 modifies dendritic cell responses to microbial ligands.},
  author={Remo Frei and Ruth Ferstl and Patrycja Konieczna and Mario Ziegler and T{\"u}nde Simon and Tulia Mateus Rugeles and Susanne Mailand and Takeshi Watanabe and R Lauener and Cezmi A. Akdis and Liam O'Mahony},
  journal={The Journal of allergy and clinical immunology},
  volume={132 1},
BACKGROUND The induction of tolerance and protective immunity to microbes is significantly influenced by host- and microbiota-derived metabolites, such as histamine. OBJECTIVE We sought to identify the molecular mechanisms for histamine-mediated modulation of pattern recognition receptor signaling. METHODS Human monocyte-derived dendritic cells (MDDCs), myeloid dendritic cells, and plasmacytoid dendritic cells were examined. Cytokine secretion, gene expression, and transcription factor… CONTINUE READING
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