Histamine protects bone marrow against cellular damage induced by ionising radiation

@article{Medina2010HistaminePB,
  title={Histamine protects bone marrow against cellular damage induced by ionising radiation},
  author={Vanina A. Medina and M{\'a}ximo Croci and Eliana Carabajal and Rosa M. Bergoc and Elena S. Rivera},
  journal={International Journal of Radiation Biology},
  year={2010},
  volume={86},
  pages={283 - 290}
}
Purpose: Based on our previous data on the histamine radioprotective effect on small intestine, in the present work we aimed to determine whether histamine is able to protect bone marrow cells against ionising radiation damage. Materials and methods: 56 mice and 40 rats were divided into four groups. Histamine and histamine-irradiated groups received a daily subcutaneous histamine injection (0.1 mg/kg) starting 24 h before irradiation. Irradiated groups received a single dose on whole-body… 
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    International journal of radiation biology
  • 2015
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Enhancement of ionizing radiation response by histamine in vitro and in vivo in human breast cancer
TLDR
Investigating the combinatorial effect of histamine or its receptor ligands and gamma radiation in vitro on the radiobiological response of 2 breast cancer cell lines concluded that histamine increased radiation response of breast cancer cells, suggesting that it could be used as a potential adjuvant to enhance the efficacy of radiotherapy.
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Although histamine diminished catalase activity in nonirradiated cells, it only partially hindered the increase observed in irradiated cells and could not modify radiosensitivity, and an increment in reactive oxygen species levels produced an augmentation in GSK-3β phosphorylation and suppressed cell proliferation.
PANC-1 cells proliferative response to ionizing radiation is related to GSK-3β phosphorylation.
TLDR
Although histamine diminished catalase activity in nonirradiated cells, it only partially hindered the increase observed in irradiated cells and could not modify radiosensitivity, and an increment in reactive oxygen species levels produced an augmentation in GSK-3β phosphorylation and suppressed cell proliferation.
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