Histamine potentiates N-methyl-d-aspartate responses in acutely isolated hippocampal neurons

@article{Vorobjev1993HistaminePN,
  title={Histamine potentiates N-methyl-d-aspartate responses in acutely isolated hippocampal neurons},
  author={Vladimir S. Vorobjev and Irina N. Sharonova and Ita B. Walsh and Helmut L. Haas},
  journal={Neuron},
  year={1993},
  volume={11},
  pages={837-844}
}
N-methyl-D-aspartate (NMDA)-evoked currents were recorded from acutely isolated rat hippocampal neurons, using the whole-cell patch-clamp technique and a rapid perfusion system. Histamine, at concentrations from 0.5 to 100 microM, reversibly enhanced NMDA currents by up to 50%. The effect cannot be ascribed to activation of the known histamine receptors (H1, H2, H3) but is occluded by spermine. These results suggest an interaction of histamine with the polyamine-binding site on the NMDA… CONTINUE READING
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