Histamine-mediated autocrine signaling in mesenteric perilymphatic mast cells.

  title={Histamine-mediated autocrine signaling in mesenteric perilymphatic mast cells.},
  author={Sarit Pal and Olga Yu. Gasheva and David C. Zawieja and Cynthia Meininger and Anatoliy A. Gashev},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  • Sarit Pal, O. Gasheva, A. Gashev
  • Published 8 January 2020
  • Biology, Medicine
  • American journal of physiology. Regulatory, integrative and comparative physiology
Lymphatic vessels play a critical role in mounting a proper immune response by trafficking peripheral immune cells to draining lymph nodes. Mast cells (MCs) are well known for their roles in type I hypersensitivity reactions but little is known about their secretory regulation in the lymphatic niche. MCs, as innate sensor and effector cells, reside close to mesenteric lymphatic vessels (MLVs) and their activation and ability to release histamine influences the lymphatic microenvironment in a… 

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