Histamine levels and clonic convulsions of electrically-induced seizure in mice: the effects of α-fluoromethylhistidine and metoprine

@article{Yokoyama2004HistamineLA,
  title={Histamine levels and clonic convulsions of electrically-induced seizure in mice: the effects of $\alpha$-fluoromethylhistidine and metoprine},
  author={H. Yokoyama and K. Onodera and K. Maeyama and K. Yanai and K. Iinuma and L. Tuomisto and T. Watanabe},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2004},
  volume={346},
  pages={40-45}
}
SummaryThe purpose of this study was to investigate the possible role of the central histaminergic neuron system in electrically-induced seizure in mice. For this purpose, we examined the effects of intraperitoneal (i. p.) injections of histaminergic agents, such as l-histidine, metoprine, and α-fluoromethylhistidine (FMH), on electrically-induced seizure. l-Histidine decreased the duration of clonic convulsion in electrically-induced seizure, but not affected that of tonic convulsion. This… Expand
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