Histamine is a powerful stimulator of cyclic AMP formation in chick pineal gland

  title={Histamine is a powerful stimulator of cyclic AMP formation in chick pineal gland},
  author={Jerzy Zygmunt Nowak and B. Sek},
  journal={Agents and Actions},
Histamine (HA) potently stimulated both basal and forskolin-activated cAMP formation in chick pineal gland. The action of HA was mimicked by 4-methyl-HA, and to some extent by 2-methyl-HA and 2-thiazolylethylamine (2TEA), but not by dimaprit, (R)-α-methyl-HAtele-methyl-HA, and several other imidazole-derivatives. The stimulatory actions of all the compounds were antagonized by ranitidine and tiotidine (HA H2-receptor antagonists), and were not affected by mepyramine and thioperamide (HA H1- and… CONTINUE READING


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