Histamine inhibits activation of human neutrophils and HL-60 leukemic cells via H2-receptors

@article{Burde1989HistamineIA,
  title={Histamine inhibits activation of human neutrophils and HL-60 leukemic cells via H2-receptors},
  author={Rahel Burde and Roland Seifert and Armin Buschauerz and Guenter Schultz},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1989},
  volume={340},
  pages={671-678}
}
The effects of prostaglandin E1 (PGE1) and histamine on activation of superoxide (O22/su−) formation, exocytosis of β-glucuronidase and aggregation in human neutrophils and HL-60 leukemic cells were studied. PGE1, histamine and impromidine, a potent H2-agonist, inhibited O2 − formation in neutrophils induced by the chemotactic peptide, N-formyl-l,-methionyl-l-leucyl-l-phenylalanine (fMet-Leu-Phe) with IC50 values of 0.5 µM, 8 µM and 2 µM, respectively. The full H1-agonist and weak partial H2… CONTINUE READING
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Histamine receptors

  • A Buschauer, W Schunack, J-M Arrang, M Garbarg, JC Schwartz, JM Young
  • 1989
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