Histamine inhibits KCNQ2/KCNQ3 channel current via recombinant histamine H(1) receptors.

@article{Guo2002HistamineIK,
  title={Histamine inhibits KCNQ2/KCNQ3 channel current via recombinant histamine H(1) receptors.},
  author={Juan Guo and Geoffery G Schofield},
  journal={Neuroscience letters},
  year={2002},
  volume={328 3},
  pages={285-8}
}
A variety of agonists are capable of inhibiting M-type K(+) channels via the activation of G-protein coupled receptors which converge on phospholipase-C (PLC) via the activation of G(q/11). Histamine acting via H(1) receptors also activates PLC but to date has not been shown to produce M-current (I(M)) modulation. We postulated that histamine would modulate… CONTINUE READING