Histamine influences body temperature by acting at H1 and H3 receptors on distinct populations of preoptic neurons.

@article{Lundius2010HistamineIB,
  title={Histamine influences body temperature by acting at H1 and H3 receptors on distinct populations of preoptic neurons.},
  author={Ebba Gregorsson Lundius and Manuel S{\'a}nchez-Alav{\'e}z and Yasmin Ghochani and Joseph Klaus and Iustin V. Tabarean},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2010},
  volume={30 12},
  pages={
          4369-81
        }
}
The preoptic area/anterior hypothalamus, a region that contains neurons that control thermoregulation, is the main locus at which histamine affects body temperature. Here we report that histamine reduced the spontaneous firing rate of GABAergic preoptic neurons by activating H3 subtype histamine receptors. This effect involved a decrease in the level of phosphorylation of the extracellular signal-regulated kinase and was not dependent on synaptic activity. Furthermore, a population of non… CONTINUE READING

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