Histamine induces migraine via the H1-receptor. Support for the NO hypothesis of migraine.

@article{Lassen1995HistamineIM,
  title={Histamine induces migraine via the H1-receptor. Support for the NO hypothesis of migraine.},
  author={Lisbeth Hjorth Lassen and Lise Lykke Thomsen and Jes Olesen},
  journal={Neuroreport},
  year={1995},
  volume={6 11},
  pages={1475-9}
}
In primates, histamine activates cerebral endothelial H1-receptors leading to formation of nitric oxide (NO). Twenty migraine patients received pretreatment with placebo or the histamine-H1-receptor antagonist, mepyramine, in a randomized, double blind fashion, followed in both groups by i.v. histamine (0.5 microgram kg-1 min-1 for 20 min). Headache characteristics were subsequently observed for 12 h. In patients given placebo histamine caused immediate headache during the infusion followed by… CONTINUE READING