Histamine induces melanogenesis and morphologic changes by protein kinase A activation via H2 receptors in human normal melanocytes.

@article{Yoshida2000HistamineIM,
  title={Histamine induces melanogenesis and morphologic changes by protein kinase A activation via H2 receptors in human normal melanocytes.},
  author={Masaki Yoshida and Yoshito Takahashi and Shintaro Inoue},
  journal={The Journal of investigative dermatology},
  year={2000},
  volume={114 2},
  pages={334-42}
}
Hyperpigmentation frequently accompanies chronic or acute inflammation. A number of inflammatory mediators have been shown to stimulate melanin synthesis in human melanocytes. Although histamine is ubiquitous as an inflammatory factor, its involvement in pigmentation remains obscure. In this work, we examined the effects of histamine on cultured human melanocytes. Treatment of human melanocytes with 0.1-10 microM histamine evoked morphologic changes and increases in tyrosinase activity. The… CONTINUE READING

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