Histamine induces Toll-like receptor 2 and 4 expression in endothelial cells and enhances sensitivity to Gram-positive and Gram-negative bacterial cell wall components.

@article{Talreja2004HistamineIT,
  title={Histamine induces Toll-like receptor 2 and 4 expression in endothelial cells and enhances sensitivity to Gram-positive and Gram-negative bacterial cell wall components.},
  author={Jaya Talreja and Mohammad H. Kabir and Michael B Filla and Daniel J. Stechschulte and Kottarappat N. Dileepan},
  journal={Immunology},
  year={2004},
  volume={113 2},
  pages={224-33}
}
Histamine is a major inflammatory molecule released from the mast cell, and is known to activate endothelial cells. However, its ability to modulate endothelial responses to bacterial products has not been evaluated. In this study we determined the ability of histamine to modulate inflammatory responses of endothelial cells to Gram-negative and Gram-positive bacterial cell wall components and assessed the role of Toll-like receptors (TLR) 2 and 4 in the co-operation between histamine and… CONTINUE READING