Histamine induces MUC5AC expression via a hCLCA1 pathway.

  title={Histamine induces MUC5AC expression via a hCLCA1 pathway.},
  author={Yong Min Kim and T W Won and Si Whan Kim and Y. G. Min and Chul Hee Lee and Chae-Seo Rhee},
  volume={80 4},
BACKGROUND Histamine is an important inflammatory mediator and associated with early phase allergic response. However, the involvement of histamine in mucin gene expression or production has not been elucidated. OBJECTIVE The aim of this study is to investigate whether histamine induces MUC5AC production in NCI-H292 cells, and to evaluate which pathway is involved in this mucin production. METHODS MUC5AC production in NCI-H292 cells was analyzed by RT-PCR, immunoassay and immunocytochemical… CONTINUE READING

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