Histamine induces IL-6 production by human endothelial cells.

@article{Delneste1994HistamineII,
  title={Histamine induces IL-6 production by human endothelial cells.},
  author={Yves Delneste and Philippe Lassalle and Patricia Jeannin and Michel Joseph and A. B. Tonnel and Philippe Gosset},
  journal={Clinical and experimental immunology},
  year={1994},
  volume={98 2},
  pages={344-9}
}
Histamine is one of the major mediators implicated in the physiopathology of allergy. On vascular endothelium, histamine mainly induces early effects: an increase in vasopermeability leading to oedema, a release of lipid mediators and a transient expression of P-selectin. The aim of this study was to evaluate the effects of histamine on adhesion molecule expression and IL-6 production by human endothelial cells. Histamine did not modulate the expression of intercellular adhesion molecule-1… CONTINUE READING

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