Histamine-induced secretion of lymphocyte chemoattractant factor from CD8+ T cells is independent of transcription and translation. Evidence for constitutive protein synthesis and storage.

@article{Laberge1995HistamineinducedSO,
  title={Histamine-induced secretion of lymphocyte chemoattractant factor from CD8+ T cells is independent of transcription and translation. Evidence for constitutive protein synthesis and storage.},
  author={Sophie Laberge and William W. Cruikshank and H Kornfeld and David M. Center},
  journal={Journal of immunology},
  year={1995},
  volume={155 6},
  pages={
          2902-10
        }
}
We have reported previously that histamine induces the release of the CD4+ cell-specific lymphocyte chemoattractant factor (LCF) into the culture supernatants of CD8+ cells between 1 and 4 h following stimulation. To determine the mechanism of histamine-induced secretion of LCF, we evaluated the effects of inhibitors of gene transcription and translation on LCF production, and determined the effects of histamine stimulation on LCF mRNA induction and stability. The histamine-induced secretion of… CONTINUE READING
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