Histamine-induced actin polymerization in human eosinophils: an imaging approach for histamine H4 receptor.

@article{Barnard2008HistamineinducedAP,
  title={Histamine-induced actin polymerization in human eosinophils: an imaging approach for histamine H4 receptor.},
  author={Ruth Emma Barnard and Adrian Barnard and G. Arthur Salmon and Wai Man Liu and Sasha Sreckovic},
  journal={Cytometry. Part A : the journal of the International Society for Analytical Cytology},
  year={2008},
  volume={73 4},
  pages={
          299-304
        }
}
Image-based screening, a new and flexible tool in the drug discovery cascade, is amenable to many different targets. This article describes a particular use of the Cellomics ArrayScan in developing a functional screen for histamine H(4) receptor (H(4)R) antagonists that have potential utility in inflammatory diseases of the airways such as asthma, with H(4)R being expressed on a wide variety of immune cells including eosinophils. Exposure to histamine causes eosinophils to migrate from the… CONTINUE READING
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