Histamine in two component system-mediated bacterial signaling.

@article{Kyriakidis2012HistamineIT,
  title={Histamine in two component system-mediated bacterial signaling.},
  author={Dimitrios A. Kyriakidis and Marina C. Theodorou and Ekaterini Tiligada},
  journal={Frontiers in bioscience},
  year={2012},
  volume={17},
  pages={
          1108-19
        }
}
Histamine is a key mediator governing vital cellular processes in mammals beyond its decisive role in inflammation. Recent evidence implies additional actions in both eukaryotes and prokaryotes. Besides its function in host defense against bacterial infections, histamine elicits largely undefined actions in microorganisms that may contribute to bacteria-host interactions. Bacterial proliferation and adaptation are governed by sophisticated signal transduction networks, including the versatile… 

Figures from this paper

High-Affinity Chemotaxis to Histamine Mediated by the TlpQ Chemoreceptor of the Human Pathogen Pseudomonas aeruginosa

TLDR
The first report of bacterial histamine chemotaxis in the human pathogen Pseudomonas aeruginosa is reported, and this chemotactic response is mediated by the concerted action of the TlpQ, PctA, and PctC chemoreceptors, which display differing sensitivities to histamine.

High-Affinity Chemotaxis to Histamine Mediated by the TlpQ Chemoreceptor of the Human Pathogen <named-content content-type='genus-species'>Pseudomonas aeruginosa</named-content>

Histamine is a key biological signaling molecule. It acts as a neurotransmitter in the central and peripheral nervous systems and coordinates local inflammatory responses by modulating the activity

Editorial: Route by which monocytes leave the brain is revealed

TLDR
The studies by Gschwandtner et al. highlight the promising value of histamine in orchestrating the complex immune response in dermal inflammation, and they raise challenging questions about the mechanisms underlying the multiple interconnected systems that contribute to the pathogenesis of chronic inflammation in vivo.

Biogenic amines at a low level of evolution: Production, functions and regulation in the unicellular Tetrahymena.

  • G. Csaba
  • Biology
    Acta microbiologica et immunologica Hungarica
  • 2015
TLDR
The critical review discusses the role of amines in the early stages of evolution and compares this to their functions in mammals and tries to give answer how and why biogenic amines were selected to hormones and why new functions formed for them in higher ranked animals, preserving also the ancient ones.

Different Evolutionary Modifications as a Guide to Rewire Two-Component Systems

TLDR
Detailed data, concrete alignments, and structure analysis is given on three general modification scenarios, where TCS was rewired for new responses and functions: exchanges in the sequence within single TCS domains, and addition of new components modulating TCS function.

A subset of histamine receptor ligands improve thermotolerance of the yeast Saccharomyces cerevisiae

TLDR
The effects of antihistamines on the heat shock (HS) response in yeast is investigated, thereby exploring their functions in a well‐established histamine receptor (HxR)‐free model.

Role of Marine Bacterial Contaminants in Histamine Formation in Seafood Products: A Review

TLDR
The role of histamine-producing bacteria in fish and seafood products with consequences for human food poisoning following consumption are discussed and methods to control their activity in countering histamine production are proposed.

The Neglected Role of Histamine in Alzheimer’s Disease

TLDR
This review focuses on the role of histamine and its receptors in the treatment of AD, and it is hoped that histamine could be an effective therapeutic factor in the Treatment of AD.

Editorial: Is histamine the missing link in chronic inflammation?

  • E. Tiligada
  • Biology, Medicine
    Journal of leukocyte biology
  • 2012
TLDR
Human pulmonary microvascular endothelial cells support productive replication of highly pathogenic avian influenza viruses: possible involvement in the pathogenesis of human H5N1 virus infection.

References

SHOWING 1-10 OF 114 REFERENCES

Signal transduction and adaptive regulation through bacterial two-component systems: the Escherichia coli AtoSC paradigm

TLDR
The AtoSC TCS functional modulation by polyamines, histamine and Ca2+, as well as the role of AtoC as transcriptional regulator, add new promising perspectives in the physiological significance and potential pharmacological exploitation of this TCS in cell proliferation, bacteria–host interactions, chemotaxis, and adaptation.

Histamine modulates the cellular stress response in yeast

TLDR
In conclusion, histamine was capable of inducing the adaptive phenotype, while the contribution of HSPs and tubulin and the potential implications remain largely elusive.

A Novel Two-Component Signaling System That Activates Transcription of an Enterohemorrhagic Escherichia coli Effector Involved in Remodeling of Host Actin

TLDR
A novel two-component system, QseEF (quorum-sensing E. coli regulators E and F), which is part of the AI-3/epinephrine/norepinephrine signaling system is described, which is a two- component system involved in the regulation of AE lesion formation by EHEC.

Two-component signal transduction as potential drug targets in pathogenic bacteria.

Calcium signalling in bacteria

TLDR
This review presents recent developments of calcium in bacteria as it relates to signal transduction and suggests the possibility that calcium signalTransduction exists in bacteria.

Fungal Histidine Kinases

TLDR
Because some phosphorelay proteins are essential for virulence of microbial pathogens, including the yeast fungus Candida albicans, novel antibiotics targeted to phosphorelays may be effective against eukaryotic pathogens without causing host cell damage.

Investigation of in vivo cross-talk between key two-component systems of Escherichia coli.

TLDR
The authors have investigated whether, and to what extent, these separate systems form an interacting network in vivo, focussing on interactions between four major systems, involved in the responses to the availability of phosphorylated sugars (Uhp), phosphate (Pho), nitrogen (Ntr) and oxygen (Arc).

Effect of histamine on the signal transduction of the AtoS–AtoC two component system and involvement in poly-(R)-3-hydroxybutyrate biosynthesis in Escherichia coli

TLDR
The reported data provide the first evidence for a differential modulator role of histamine and compound 48/80 on the AtoS–AtoC two-component system signaling in potentially pathogenic bacteria, leading to a new perspective on their symbiotic behavior.
...