Histamine in rheumatoid arthritis.

  title={Histamine in rheumatoid arthritis.},
  author={M Adlesic and Margareta Verdrengh and Maria Bokarewa and Leif Dahlberg and Simon J Foster and Andrej Tarkowski},
  journal={Scandinavian journal of immunology},
  volume={65 6},
Rheumatoid arthritis (RA) is an autoimmune disease characterized by a persistent inflammation of the synovium, leading to the erosion of articular cartilage and bone. Synovial mast cells and their effector molecule, histamine, receive increased attention as mediators of joint inflammation. The aim of our study was to analyse levels of free histamine in serum and joint fluid of RA patients and to evaluate the potential inflammatogenic properties of histamine in vivo and in vitro. Histamine… CONTINUE READING


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