Histamine excites pedunculopontine neurones in guinea pig brainstem slices.

@article{Khateb1990HistamineEP,
  title={Histamine excites pedunculopontine neurones in guinea pig brainstem slices.},
  author={Asaid Khateb and Mauro Serafin and Michel M{\"u}hlethaler},
  journal={Neuroscience letters},
  year={1990},
  volume={112 2-3},
  pages={257-62}
}
Intracellular recordings were obtained from pedunculopontine tegmental nuclei neurones in guinea pig brainstem slices. These neurones were characterized by the presence of a slow regular firing (around 3 spikes/s), a broad action potential (more than 1 ms) and a transient rectification indicating the presence of an A current. Bath-application of histamine at 10(-4) or 10(-5) M induced a reversible increase in spontaneous firing. In presence of tetrodotoxin (1 microM), the effect of histamine… CONTINUE READING